Tissue engineering is now recognized as a way to lessen the global disease burden: novel methods for pancreatic islet regeneration can address diabetes; autologous cells for heart muscle regeneration can address coronary artery disease; and nerve regeneration technologies can be used to treat stroke. This course describes strategies of tissue engineering, and focuses on the diseases tissue engineering can address. Each lecture identifies a specific disease (coronary artery disease, stroke, diabetes) and describes tissue-engineered scaffolds that can alleviate the disease. Students learn the underlying pathology of the disease, understand the latest advances in tissue engineering for treating the disease, and discuss prospective research areas for novel biomaterials to modify the disease process. In addition, students gain an appreciation of clinical trials of tissue-engineered scaffolds, as well as commercialization of tissue engineering.